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Abstract #3547

PET/MR in pancreatic cancer: correlation between overall survival and functional imaging biomarkers from DCE-MRI, DWI, MR spectroscopy and PET

Bang-Bin Chen1, Yu-Wen Tien2, Ming-Chu Chang3, Mei-Fang Cheng4, Shih-Hung Yang5, and Tiffany Ting-Fang Shih6,7

1Department of Medical Imaging and Radiology, National Taiwan University Medical School and Hospital, Taipei, Taiwan, 2Department of Surgery, National Taiwan University Medical School and Hospital, 3Department of Internal Medicine, National Taiwan University Medical School and Hospital, 4Department of Nuclear Medicine, National Taiwan University Medical School and Hospital, 5Department of Oncology, National Taiwan University Medical School and Hospital, 6Departmen of Radiology, National Taiwan University Medical School and Hospital, Taipei, Taiwan, 7Department of Medial Imaging, Taipei City Hospital

The purpose of this study is to evaluate the association of imaging biomarkers from PET/MR with overall survival in pancreatic cancer patients. Sixty-four patients with pathologically-proven pancreatic adenocarcinoma underwent PET/MRI before treatment. The imaging biomarkers included Ktrans and Peak from DCE-MRI, minimal apparent diffusion coefficient from DWI, choline from MR spectroscopy, standard uptake values, metabolic tumor volume, and total lesion glycolysis of the tumors. Among all imaging parameters, Peak was found to be an independent predictor for overall survival in these patients. Thus, the imaging biomarkers from PET/MRI reflect different tumor characteristics and may predict survival outcome in these patients.

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Abstract