We compared directly acquired diffusion-weighted imaging (DWI) at b-values of 1500 s/mm2 and 2000 s/mm2 with computed DWI (cDWI) at the same b-values, which was calculated from directly acquired DWI data at b-values of 0 s/mm2 and 1000 s/mm2. Our main result is that the incidence of clear hyperintense pancreatic adenocarcinomas was significantly higher on cDWI at a b-value of 1500 s/mm2 than on directly acquired DWI at a b-value of 1000 s/mm2 (P < 0.001) and was comparable to the incidence on directly acquired DWI at a b-value of 1500 s/mm2, suggesting that cDWI to a b-value of 1500 s/mm2 has diagnostic merit.
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