Abstract #3525

Quantitative estimation of IVIM parameters and response evaluation after neoadjuvant chemotherapy in Osteosarcoma

Esha Baidya Kayal¹, Devasenathipathy K², Kedar Khare³, Raju Sharma², Sameer Bakhshi⁴, and Amit Mehndiratta^1,5

¹Center for Biomedical Engineering, Indian Institute of Technology, New Delhi, India, ²Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, India, ³Department of Physics, Indian Institute of Technology, New Delhi, India, ⁴Medical Oncology, Dr. B.R.Ambedkar Institute-Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India, ⁵Department of Biomedical Engineering, All India Institute of Medical Sciences, New Delhi, India

Histological necrosis is the current gold standard for response evaluation in Osteosarcoma treated with neoadjuvant chemotherapy (NAC). However it is applicable only after tumour resection on completion of NAC. Thus, a non-invasive early marker of NAC response is desirable. We performed NAC response evaluation using Intra-voxel Incoherent Motion (IVIM) Diffusion weighted MRI using tumour volume change and histogram analysis. Tumour volume change and histogram analysis revealed similar and clinically useful information in chemotherapy response to Osteosarcoma.

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