Abstract #3504

Compressed sensing diffusion spectrum imaging as a forward-looking alternative to multi-shell diffusion MRI in population imaging

Alexandra Tobisch¹, Rüdiger Stirnberg¹, Robbert Leonard Harms², Thomas Schultz³, Alard Roebroeck², Monique Breteler¹, and Tony Stöcker¹

¹German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, ²Faculty of Psychology & Neuroscience, Maastricht University, Maastricht, Netherlands, ³University of Bonn, Institute of Computer Science, Bonn, Germany

This study investigates the applicability of two advanced diffusion MRI protocols in population imaging: 3-shell High Angular Resolution Diffusion Imaging (HARDI) and Diffusion Spectrum Imaging accelerated through Compressed Sensing theory (CS-DSI). Group analysis of 20 subjects indicates that CS-DSI performs comparable to 3-shell HARDI in the estimation of microstructure parameters and adds the advantage of high b-value acquisitions, further complimentary biomarkers from the diffusion propagator and a high potential to deliver data well-suited for future developments.

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