Abstract #3449

Multiparametric MR characterisation of a high-fat, high-cholesterol diet rodent model of liver disease

Manil Chouhan¹, Tim Bray¹, John Connell², Jane MacNaughtan³, Alan Bainbridge⁴, Helen Jones³, Abeba Habtieson³, Nathan Davies³, Rajiv Jalan³, Shonit Punwani¹, Tammy Kalber², Mark Lythgoe², Margaret Hall-Craggs¹, Rajeshwar Mookerjee³, and Stuart Taylor¹

¹UCL Centre for Medical Imaging, University College London, London, United Kingdom, ²UCL Centre for Advanced Biomedical Imaging, University College London, London, United Kingdom, ³UCL Institute for Liver and Digestive Health, University College London, London, United Kingdom, ⁴Department of Medical Physicist, University College London Hospitals NHS Trust, London, United Kingdom

There is a growing interest in the development of new animal models of non-alcoholic fatty liver disease. In this study, we use T1, proton density fat fraction (PDFF) and R2* mapping to characterise hepatic parenchymal tissue and the evolution of MR properties over time in a high-fat, high-cholesterol diet model of fatty liver disease.

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