There is an increasing demand for specific tissue microstructure markers that can be related to demyelination and axonal loss. Quantitative MRI techniques are sensitive to microscopic changes but tend to be non-specific. We propose to combine NODDI, a popular MRI diffusion technique, with mcDESPOT, a multi-component relaxation analysis technique, to obtain separate estimates of the volumes of myelin, extra-cellular and intra-cellular spaces. This multimodal MR approach opens the possibility to disentangle changes to myelination and axonal density with the exciting prospect of achieving in vivo histology.
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