No previous in vivo studies have investigated drug-related changes of microstructural integrity of amygdala-hippocampus-nucleus accumbens circuit using diffusion tensor imaging. This study demonstrated reduced microstructural integrity of this circuit in methamphetamine users by applying automated and semi-automated segmentation techniques to acquire regions of interest. The microstructural impairment of hippocampal subiculum and basolateral amygdala might be implicated in the development of anxiety and psychosis. Enhanced anatomical connectivity between left BLA and bilateral NAc may underlie the relapse of MA intake and production of psychosis.
This abstract and the presentation materials are available to members only; a login is required.