Abstract #3319

Hyperpolarized Helium-3 MRI Insights into Subtypes of Emphysema in Chronic Obstructive Pulmonary Disease (COPD)

Yanping Sun¹, Christian M. Lo Cascio¹, Pallavi P Balte¹, Jia Guo², Emilia A Hermann¹, Firas S. Ahmed³, Belinda M. Dsouza³, Robert M. Steiner³, Jay S. Leb³, Casandra Almonte¹, Paul JC Hughes⁴, Stephen M. Dashnaw³, James M. Wild⁴, Martin R. Prince^3,5, Emlyn W. Hughes⁶, Benjamin Smith¹, Eric Hoffman⁷, and R. Graham Barr¹

¹Department of Medicine, Columbia University Medical Center, New York, NY, United States, ²Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, NY, United States, ³Department of Radiology, Columbia University Medical Center, New York, NY, United States, ⁴Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom, ⁵Department of Radiology, Weill Cornell Medical Center, ⁶Department of Physics, Columbia University Medical Center, New York, NY, United States, ⁷Department of Radiology, University of Iowa Carver College of Medicine, IA, United States

To examine the association of ventilation defects on 3He MRI with emphysema subtypes, participants (n=41) between 60 and 85 years of age with 10 or more packyears of smoking were studied. Ventilation defect percentage (VDP) was associated with percent emphysema (r =0.43; p=0.008) and, with borderline statistical significance, extent of visual emphysema (r=0.31; p=0.07). There was no relationship between VDP and extent of centrilobular (p=0.61) or panlobular (P=0.98) emphysema. VDP was associated with extent of paraseptal emphysema (PSE) (r=0.42; p=0.01). These findings suggest that small airways disease may be a component of PSE but not other subtypes of emphysema.

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