Previous study showed that hyperpolarized xenon-129 MRI is highly sensitive in detecting functional changes in lungs with interstitial lung diseases (ILD). The degree to which these changes vary regionally in the lung has not been determined, however. In this work, we compared abnormalities in lung function in different regions of the lung, and found significant differences in xenon-129 gas uptake between subjects with ILD and controls. These results support that xenon-129 MRI may provide unique information about lung physiology associated with lung fibrosis.
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