Abstract #3249

Quantitative MRI measurement of the interplay between myocardial function, perfusion, structure and metabolism during acute and chronic remodeling in a porcine model of myocardial infarction

Smita Sampath¹, Sarayu Annamalai Parimal², Wei Huang³, Ibrahim Mazlan^4,5, Grace Croft^4,5, Teresa Totman^4,5, Yvonne Wei Zheng Tay⁶, Elaine Manigbas⁶, Miko May Lee Chang⁷, Anqi Qiu⁷, Michael Klimas⁸, Jeffrey L Evelhoch⁸, Dominique PV de Kleijn^4,5, and Chih-Liang Chin¹

¹Translational Biomarkers, Merck Sharp & Dohme, Singapore, Singapore, ²Translational Biomarkers, Merck Sharp & Dohme, Singapore, ³Advanced Imaging Research Center, Oregon Health and Science University, Portland, OR, United States, ⁴Cardiovascular Research Institute, National University Heart Center, Singapore, ⁵Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, ⁶Comparative Medicine Imaging Facility, Center for Life Sciences, National University of Singapore, Singapore, ⁷Department of Biomedical Engineering, National University of Singapore, Singapore, ⁸Translational Biomarkers, Merck & Co., Inc., West Point, PA, United States

We present a comprehensive characterization of LV structure, function, perfusion and metabolism in a porcine animal model with myocardial infarction with view to develop a translational platform for future testing of safety and efficacy of novel heart failure therapeutics. Dynamic contrast enhanced MRI and tagging MRI are employed to obtain non-invasive quantitative magnetic resonance imaging (MRI) biomarkers for characterization. Results demonstrate an acute decrease in function and perfusion in the infarct region and functional compensation in the remote region with associated increased metabolic activity. Chronic remodeling is associated with decreased metabolic activity in the infarct region along with increased fibrosis.

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