In vivo cardiac Intravoxel Incoherent Motion Imaging (IVIM) offers the potential to estimate myocardial perfusion without the need for contrast agents. The IVIM parameter estimates, however, suffer from low signal-to-noise ratio, patient motion and are depending on imaging settings as well as on diffusion gradient shapes. In the present work, further evidence is presented that estimation of perfusion using a second-order motion compensated diffusion weighted sequence in the in vivo human heart is possible.
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