Abstract #3225

Comparison of Doppler Echocardiography Mean Transvalvular Aortic Pressure Gradient to 4D Flow MRI

Michael James Rose¹, Kelly Jarvis^2,3, Susanne Schnell², James D Thomas⁴, Joshua D Robinson^1,5,6, Cynthia K Rigsby^1,2, Michael Markl^2,3, and Alex J Barker²

¹Medical Imaging, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, United States, ²Department of Radiology, Feinberg School of Medicine, Northwestern University, ³Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, ⁴Division of Cardiology, Feinberg School of Medicine, Northwestern University, ⁵Division of Pediatric Cardiology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, United States, ⁶Department of Pediatrics, Feinberg School of Medicine, Northwestern University

Mean and peak pressure gradients are an important measure of aortic stenosis severity. In this study, we present a novel method for measuring mean pressure gradients using 4D flow MRI. 4D flow MRI peak and mean pressure gradients were measured in 23 pediatric BAV patients and compared to Doppler echocardiography (echo). There was no significant difference between 4D flow MRI and echo in peak or mean pressure gradients. 4D flow MRI mean pressure gradients correlated better with echo than peak pressure gradients (R2= 0.78 vs. R2=0.27), suggesting 4D flow to be better suited for measuring mean pressure gradients.

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