To deliver a non-invasive quantitative measure of patients with nonalcoholic fatty liver disease (NAFLD) who are likely to develop a fibrotic pathology, we characterized the natural history of a nonalcoholic steatohepatitis (NASH) mouse model using MRI. Characterization included fat quantification and MR relaxometry measurements by imaging at 4 time points and comparing with histology and biochemical markers. Fibrogenesis was assessed using the novel Gd-based MR probe, Gd-Hyd which was previously shown to detect fibrogenesis in a mouse CCl4 model of liver fibrosis
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