Abstract #3204

Liver R2 Quantification at 3 Tesla in Patients with Iron Overload - Interim Validation Result

Ali Pirasteh¹, Qing Yuan¹, Changqing Wang², Diego Hernando², Scott B Reeder³, Ivan Pedrosa⁴, and Takeshi Yokoo¹

¹Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States, ²Radiology, Medical Physics, University of Wisconsin, Madison, WI, United States, ³Radiology, Medical Physics, Biomedical Engineering, Medicine, Emergency Medicine, University of Wisconsin, Madison, WI, United States, ⁴Radiology, Advanced Imaging Research Center, University of Texas Southwestern Medical Center, TX, United States

Determination of liver iron concentration (LIC) by R2-relaxometry has been extensively validated at 1.5T but feasibility of translating this technology to 3T remains uncertain. The purpose of this study was to assess the feasibility of a R2 quantification at 3T against the standard 1.5T R2 in subjects with known or suspected iron overload. In 13 subjects enrolled thus far, we found that liver R2 at 3T linearly correlated with R2 at 1.5T over observed LIC range of 0.3-32.3 mg iron/g liver. We conclude that noninvasive liver LIC determination may be feasible by R2-relaxometry at 3T.

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