Abstract #3183

Imaging non-enlarged abdominal lymph nodes and measuring their diffusion coefficient

Hannah Grace Williams^1,2, Caroline L Hoad^1,3, Luca Marciani², Gordon Moran², Giles Major², Robert Scott³, and Penny A Gowland¹

¹Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom, ²Nottingham Digestive Diseases Centre, University of Nottingham, Nottingham, United Kingdom, ³NIHR Biomedical Research Unit in Gastrointestinal and Liver Diseases, Nottingham University Hospital, Nottingham, United Kingdom

Inflammatory conditions such as Crohn’s disease cause changes in the lymphatics including enlargement and necrosis, and so improved measures of number, size and function of lymph nodes could provide novel markers of local inflammatory response. Being able to identify small nodes would allow the effect of inflammatory diseases and response to therapy to be monitored. DWIBS was used here to isolate the signal from small abdominal lymph nodes. The diffusion coefficient of the pelvic and abdominal lymph nodes and the cisterna chyli with IVIM effects eliminated, were 0.9±0.2, 1.4±0.3 and 1.7±0.6 x10^-3 mm²/s.

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