In order to investigate the effects of b-value acquisition strategies on the stability and bias of the prostate DWI results, including calculated b-value images and ADC, a framework was developed. Using the DWI data from 8 prostate patients, this study revealed that acquiring many averages at a few b-values increases bias compared to acquiring few averages at many b-values, particularly when large numbers of averages have been removed. The framework and strategies proposed in this work may provide a useful tool to design b-value acquisition protocols to achieve the stability of prostate DWI results in clinic.
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