Abstract #3120

Whole-brain vessel wall imaging within 5 minutes using compressed sensing accelerated IR-SPACE

Zhaoyang Fan¹, Xiaoming Bi², Marcel Maya³, Qi Yang^1,4, Shlee Song⁵, Nestor Gonzalez⁶, Schlick Konrad⁵, Esther Raithel⁷, Christoph Forman⁷, Gerhard Laub², and Debiao Li¹

¹Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ²Siemens Healthcare, Los Angeles, CA, United States, ³Imaging, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ⁴Xuanwu Hospital, Beijing, People's Republic of China, ⁵Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ⁶Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ⁷Siemens Healthcare, Erlangen, Germany

Inversion-recovery (IR) prepared SPACE was recently proposed as a whole-brain intracranial vessel wall imaging technique. This work aimed to investigate the feasibility of accelerating the scan from 8 min to <5 min using compressed sensing (CS). A prototype CS IR-SPACE sequence was implemented on a 3T system. Wavelet sparse regularization (λ) and iteration (Iter) were optimized for the scenario of sampling 15% of k-space data based on a volunteer study. Image quality was visually comparable between CS IR-SPACE and regular IR-SPACE scans. In addition, CS IR-SPACE and IR-SPACE showed comparable lesion delineation quality in patients despite markedly different scan times.

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