Abstract #3112

Dependence of the Precision of Myocardial Late Gadolinium Enhancement Quantification on Inversion Time Selection Simulated Using Synthetic Inversion Recovery MR Imaging

Akos Varga-Szemes¹, Rob J van der Geest², U. Joseph Schoepf¹, Carlo N De Cecco¹, Taylor M Duguay¹, and Pal Suranyi¹

¹Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, United States, ²Leiden University Medical Center, Leiden, Netherlands

Clinical late gadolinium enhancement (LGE) imaging of the myocardium requires inversion time (TI) optimization for adequate image quality. As the optimal TI (TI₀) depends on various factors, its influence on the precision of myocardial LGE quantification is of interest. In this study we aimed to prospectively investigate how the precision of LGE quantification varies in the clinically relevant TI range in 53 patients using T1-mapping-based synthetic inversion recovery (IR_synth) approach. We concluded that phase-sensitive IR_synth images provide precise quantification independent of TI, while magnitude IR_synth-based quantification is precise at TI₀ or longer TIs, but showing decreased precision below TI₀.

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