Abstract #3097

Quantitative Tissue Characterization by Magnetization Transfer-Weighted Cardiac MRI Detects Fibrosis Progression without Gadolinium in Patients with End Stage Renal Disease

Tori A Stromp^1,2, Rebecca M Kidney², Tyler J Spear², Kristin N Andres³, Joshua C Kaine³, Steve W Leung⁴, and Moriel H Vandsburger^1,2,5,6

¹Physiology, University of Kentucky, Lexington, KY, United States, ²Cardiovascular Research Center, University of Kentucky, KY, United States, ³College of Medicine, University of Kentucky, KY, United States, ⁴Gill Heart Institute, University of Kentucky, KY, United States, ⁵Biomedical Engineering, University of Kentucky, KY, United States, ⁶Bioengineering, University of California Berkeley, Berkeley, United States

Long term hemodialysis treatment for end stage renal disease (ESRD) is associated with a time dependent increase in cardiac death. The inability to use late gadolinium enhancement (LGE) cardiac MRI (CMR) in patients with renal dysfunction impedes the noninvasive monitoring of fibrosis progression and appropriate treatment selection in the population. We used magnetization transfer (MT) weighted CMR to monitor the progression of ventricular fibrosis over 1 year in patients with ESRD. While no major changes in hypertrophy or contractility were apparent, pervasive increases in myocardial signal was measured by MT-weighted CMR, consistent with reduced MT and progressive fibrosis development.

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