Abstract #3094

Hyperpolarized [1-13C]-MRI in an ectothermic reptile

Kasper Hansen^1,2, Per Mose Nielsen³, Esben Søvsø Szocska Hansen^3,4, Cathrine Williams¹, William Joyce¹, Michael Pedersen², Tobias Wang¹, and Christoffer Laustsen³

¹Section for Zoophysiology (Department of Bioscience), Aarhus University, Aarhus C, Denmark, ²Comparative Medicine Lab (Department of Clinical Medicine), Aarhus University, Aarhus N, Denmark, ³MR Research Centre (Department of Clinical Medicine), Aarhus University, Aarhus N, Denmark, ⁴Danish Diabetes Academy, Odense, Denmark

Many non-mammalian vertebrates hold enormous potential as “model animals” for various fields of basic physiological and biomedical research. Hyperpolarized magnetic resonance imaging (MRI) can provide quantitative in vivo information about metabolic processes including major pathways of the citric acid cycle and glycolysis via spectral differences of pyruvate intermediates. The combination of [1-¹³C]-MRI and model animals exhibiting “selected physiological traits” may be a strong tool for gaining novel insights into relevant metabolic mechanisms. In this pilot study we test, for the first time, the application of [1-¹³C]-MRI in an ectothermic reptile.

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