Abstract #3074

ROS imaging by endogenous contrast MRI: specificity and translational premises

Alessandro M Scotti^1,2,3, Rongwen Tain^1,3, Weiguo Li^4,5, Xiaohong Joe Zhou^1,2,3, and Kejia Cai^1,2,3

¹Radiology, College of Medicine, University of Illinois at Chicago, Chicago, IL, United States, ²Bioengineering, University of Illinois at Chicago, Chicago, IL, United States, ³3T Research Program, Center for MR Research, College of Medicine, University of Illinois at Chicago, Chicago, IL, United States, ⁴Research Resource Center, College of Medicine, University of Illinois at Chicago, Chicago, IL, United States, ⁵Radiology, College of Medicine, Northwestern University, Chicago, IL, United States

Detection of the elusive Reactive Oxygen Species is pivotal for understanding and diagnosis of many diseases. Recently ROS has been imaged with endogenous MRI contrasts in biological system by reduction in CEST trough combined T₁ shortening and proton exchange enhancing effects. We here show potential confounding factors such as H₂O₂, molecular oxygen, iron oxidation, pH, and temperature to be negligible in phantom studies. In addition, for the first time, we have imaged ROS by endogenous MRI contrasts under physiological conditions, at clinical MRI field strength and on ex vivo brain tissue, paving the path for clinical translation.

This abstract and the presentation materials are available to members only; a login is required.

Join Here