Abstract #3067

[18F]-DCFPyL standard uptake values correlate with apparent diffusion coefficient and choline measurements on a 3T PET-MRI in prostate cancer

Reggie Taylor^1,2,3, Irina Rachinsky⁴, Zahra Kassam^4,5, William Pavlosky⁴, Ashley Lozanski⁶, John Butler¹, Stephen Pautler^5,6, Aaron Ward^1,3, Joseph Chin^1,5,6, Ting-Yim Lee^1,3,5,7, Glenn Bauman^1,3,4,8, and Jonathan Thiessen^1,3

¹Lawson Health Research Institute, London, ON, Canada, ²Siemens Healthcare Limited, Oakville, ON, Canada, ³Medical Biophysics, Western University, London, ON, Canada, ⁴Medical Imaging, Western University, London, ON, Canada, ⁵Oncology, Western University, London, ON, Canada, ⁶Surgery, Western University, London, ON, Canada, ⁷Robarts Research Institute, London, Canada, ⁸London Regional Cancer Program, London, ON, Canada

PET data with the [¹⁸F]-DCFPyL PSMA-targeted probe to examine prostate cancer in patients scheduled for radical prostatectomy was acquired concurrently with diffusion weighted imaging and chemical shift imaging using a 3T PET-MRI. Standard uptake values (SUV) were compared to apparent diffusion coefficients (ADC) and choline plus creatine over citrate ratios (CC/C). Positive correlations existed between the SUV and CC/C in voxels with low ADC. Negative correlations existed between the ADC and SUV in voxels with high CC/C, and negative correlations also existed between the ADC and CC/C in voxels with high SUV.

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