Abstract #3058

Extrinsic MRI contrast agents based on nuclear quadrupole enhanced relaxation: Principle, requirements and characterization of promising compounds

Christian Gösweiner¹, Danuta Kruk², Per-Olof Westlund³, Fischer Roland⁴, Schlögl Martin⁴, Markus Bödenler¹, Andreas Petrovic¹, Hermann Scharfetter¹, and Stefan Spirk⁵

¹Institute of Medical Engineering, Graz University of Technology, Graz, Austria, ²Faculty of Mathematics and Computer Science, University of Warmia and Mazury in Olsztyn, Poland, ³Department of Chemistry, Umeå universitet, Sweden, ⁴Institute of Inorganic Chemistry, Graz University of Technology, Graz, Austria, ⁵Institute for Chemistry and Technology of Materials, Graz University of Technology, Graz, Austria

Quadrupole Relaxation Enhancement is a quantum mechanical effect that can be exploited to create a new generation of extrinsic contrast agents for usage in MRI. In this work we have investigated the physical requirements of such contrast agents have to meet to be useful. Based on our findings concerning nuclear quadrupole resonance-properties, spin relaxation behavior and toxicity we suggest a variety of ²⁰⁹Bi-aryl compounds. The sensitivity of these compounds onto chemical or magnetic field changes equip them with smart properties such as on/off switching of the contrast or molecular imaging.

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