Abstract #3048

High Resolution MEMRI Reveals the Purkinje Cell Layer as the Source of Contrast in the Mouse Cerebellum

Harikrishna Rallapalli^1,2, Brian J Nieman³, Aidin Arbabi³, Dulcie Vousden³, Jason P Lerch³, and Daniel H Turnbull^1,2

¹Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY, United States, ²Biomedical Imaging Graduate Program and Department of Radiology, New York University School of Medicine, New York, NY, United States, ³Mouse Imaging Centre, The Hospital for Sick Children, Toronto, ON, Canada

Imaging the developing mouse brain with conventional MRI is challenging. Manganese-enhanced MRI (MEMRI) has the potential to provide a noninvasive, in vivo approach for analyzing mutant phenotypes in the early postnatal mouse cerebellum. We present preliminary data generated using a CryoProbe (Bruker) suggesting that the primary source of Mn contrast in the mouse cerebellum is the Purkinje cell layer.

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