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Abstract #3045

Practical Considerations of Quantitative kPL Estimation in Hyperpolarized-13C Imaging in Response to Pulse Sequence Design and Parameters

Hsin-Yu Chen1,2, Jeremy W. Gordon1, Robert A. Bok1, Peng Cao1, Cornelius von Morze1, Eugene Milshteyn1,2, Ralph E. Hurd3, John Kurhanewicz1,2, Peder E.Z. Larson1,2, and Daniel B. Vigneron1,2

1Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2UCSF/UC Berkeley Graduate Program in Bioengineering, University of California, San Francisco, San Francisco, CA, United States, 3GE healthcare, Menlo Park, CA, United States

Hyperpolarized-13C MRI has recently enabled imaging of cancer pathophysiology with high spatiotemporal resolution in humans. Quantitative measure of tumor metabolism can be made possible by estimating conversion rate constants (e.g. kPL for pyruvate-to-lactate). We have identified 3 systematic sources affecting kPL estimation that were introduced by MR acquisition and pulse sequences – an RF-spoiling effect, a T2*-weighting factor, and a crusher flow-suppression phenomenon. These sources were investigated using a transgenic cancer model and simulations.

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