Abstract #3038

Examination of the hyperpolarizability of fluorinated nicotinic acids and further pyridine carboxylic acids using SABRE

Markus Plaumann¹, Frederike Euchner¹, Rainer Ringleb¹, Sara Hadjiali², Joachim Bargon³, Gerd Buntkowsky², Johannes Bernarding¹, and Ute Bommerich¹

¹Department for Biometrics and Medical Informatics, Otto-von-Guericke University Magdeburg, Magdeburg, Germany, ²Eduard-Zintl-Institute for Inorganic and Physical Chemistry, Technical University Darmstadt, Darmstadt, Germany, ³Institute of Physical and Theoretical Chemistry, University of Bonn, Bonn, Germany

Nicotinic acid and isonicotinic acid are two derivatives of pyridine carboxylic acids. Both substrates are of high interest in medical chemistry. In the current study seven fluorinated derivatives of these pyridine carboxylic acids were chosen for examination of the ¹H and ¹⁹F hyperpolarizability using the SABRE technique. Influences of the position of the carboxylic group and fluorine as well as the catalyst system concerning the achievable signal enhancements were examined. Furthermore an H/D-exchange could be observed in some cases. The presented data gives important information for future MR imaging studies.

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