GABA spectroscopy is performed at 7T in vitro and in vivo using MEGA-PRESS and MEGA-LASER sequences. MEGA-LASER is shown to be much less sensitive to B1 inhomogeneity, and having higher signal intensity than MEGA-PRESS. Relative inter- and intra-sequence variabilities with respect to B1 inhomogeneity and regional variation are reported. Higher signal intensity in MEGA-LASER is attributed to reduced chemical shift displacement artifact and less signal loss resulting from spatial effects in phase evolution of J-coupled GABA.
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