Recent high field susceptibility imaging experiments have revealed significant differences in water frequency in different tissue types. We studied the frequency distribution of choline, creatine, NAA, myo-inositol, glutamate, glutamine and GABA from gray matter- and white matter-dominant voxels. Based on data acquired from 135 normal subjects it was found that the best fit frequency of at least several metabolites are significantly dependent on tissue type composition.
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