Abstract #2971

KIDNEY CANCER SUBTYPES, IDENTIFIED BY TWO DIMENSIONAL MR SPECTROSCOPY, MAY EVENTUALLY ALLOW TREAMENT OF CLINICALLY DISTINCT DISEASES.

Aaron James Urquhart¹, Sharon Del Vecchio ^1,2, Keng Lim Ng^1,2,3, Hemamali Samaratunga⁴, Graham John Galloway¹, Peter Malycha¹, Simon Wood^1,2,3, Glenda C Gobe^1,2, and Carolyn E Mountford¹

¹Translational Research Institute, Brisbane, Australia, ²Centre for Kidney Disease Research, UQDI, The University of Queensland, Brisbane, Australia, ³Department of Urology, Princess Alexandra Hospital, Brisbane, Australia, ⁴Aquesta Pathology, Brisbane, Australia

Small renal masses, such as non-clear cell renal carcinoma (non-ccRCC), can be monitored rather than resected as morbidity is unlikely. The distinction between malignant clear cell RCC (ccRCC) from indolent RCC subtypes and benign renal tumour is not possible by imaging thus some patients undergo unnecessary surgery¹. Using 2D COrrelated SpectroscopY we report that normal renal tissue, non-ccRCC and ccRCC each has different chemical profile. ccRCC differs from normal tissue with cholesterol and lipid increased by 572% and 481% (P=0.001); decreased alanine 51% (P=0.001); valine 57% (P=0.003) and lysine 46% (P=0.005). When comparing ccRCC to the non-ccRCC there are increases in valine 48% (P=0.004) and lysine 40% (P=0.04).

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