We present an indirect 1H-[13C] MRS detection method (selective proton-observed, carbon edited (selPOCE) that can be used in the frontal lobe of human brain, allows for separation of overlapping glutamate (Glu) and glutamine (Gln) peaks and provides well-defined spatial localization of the 13C-signal. The method was successfully implemented at 4 Tesla and allowed for the selective detection of 13C-labeling in Glu and Gln in a timely manner (15 min), indicating that the selPOCE can be used for quantitative studies of brain energy metabolism and neurotransmission in a relatively small volume localized in the human frontal lobe.
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