Abstract #2927

Combined DCE-MRI and immunohistochemical analyses of cervical cancer xenografts reveal differences in the physiological background of prognostic image parameters derived from the Tofts and Brix model

Tiril Hillestad¹, Tord Hompland², Anja Nilsen², Trond Stokke^1,2, and Heidi Lyng²

¹Department of Core Facilities, Oslo University Hospital, Oslo, Norway, ²Department of Radiation Biology, Oslo University Hospital, Oslo, Norway

The Tofts and Brix parameters K^trans and A_Brix , derived from dynamic contrast-enhanced MRI (DCE-MRI), have been suggested as potential markers of hypoxia. This phenotype is associated with poor outcome in cervical cancer treated with chemoradiotherapy. In this study, DCE-MRI was combined with immunohistochemical analysis of cervical cancer xenografts, to better understand the physiological background and prognostic potential of the parameters. Through correlations with hypoxic fraction, vascular and cellular densities, derived from pimonidazole, CD31 and hematoxylin staining of tumor sections, respectively, it was shown that A_Brix could be the preferred DCE-MRI parameter for predicting hypoxia related treatment resistance in cervical cancer.

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