Abstract #2890

Quantitative evaluation of the effect of temporal resolution and acquisition duration on the accuracy of DCE-MRI measurements in a prostate phantom

Silvin P. Knight¹, Jacinta E. Browne², James F. Meaney¹, and Andrew J. Fagan¹

¹School of Medicine / National Centre for Advanced Medical Imaging (CAMI), Trinity College University of Dublin / St James's Hospital, Dublin 8, Ireland, ²School of Physics & Medical Ultrasound Physics and Technology Group, Centre of Industrial Engineering Optics, FOCAS, Dublin Institute of Technology, Dublin 8, Ireland

A novel anthropomorphic prostate phantom test device was used to investigate the effects of temporal resolution (T_res) and acquisition duration (AD) on the accuracy of contrast time-intensity curves measured using dynamic contrast-enhanced MRI. When quantitatively compared to ground truth values, large errors in derived pharmacokinetic (PK) parameters (up to 230%) were found for T_res values > 8.1 s and AD values < 360 s. The data demonstrate the critical and sensitive dependence of the accuracy of measured PK output parameter values on the acquisition protocol used, while such phantom studies can help identify optimal acquisition parameters for DCE-MRI scans

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