Recent studies showed that LV dyssynchrony and deceleration time can be recognized as an important predictor of poor outcome in patients. However, the regional myocardial function investigated by MRI is less discussed. In this study, we applied MR tissue phase mapping (TPM) and aim to investigate the myocardial dyssynchrony and action time in LV for Fabry disease (FD). We observed increased longitudinal dyssynchrony and lower systolic action time in FD group. In conclusion, the quantification of LV myocardial dyssynchrony and action time may provide useful information to comprehend the impaired cardiac manifestation and diastolic dysfunction in patients with FD.
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