Inter-center reproducibility of left ventricular circumferential strain analysis with spatial modulation of magnetization imaging analysis in healthy and repaired Tetralogy of Fallot patients

The aim of this study was to examine inter-center reproducibility of tagging magnetic resonance imaging (MRI) analysis in human patients undergoing either 1.5T or 3.0T MR examinations. A total of 20 subjects, 10 heathy subjects and 10 patients with repaired tetralogy of Fallot (rTOF), aged between 18 and 69 years, underwent either 1.5T or 3.0T MR scans. Circumferential strain (CS) from base, mid, and apex regions were analysed using CIM v8.4 at two centres (NHCS Singapore and University of Auckland). Reproducibility was moderate at the base (ICC 0.765), and excellent at the mid (0.979) and apex (0.982) regions. Overall reproducibility was excellent in both healthy controls and rTOF patients (ICC: 0.956 and 0.932), and at both 1.5T and 3.0T (0.972 and 0.940).