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Abstract #2837

Magnetic Resonance Imaging Reveals Elevated Aortic Pulse Wave Velocity in Overweight Adolescents

Jessica Elizabeth Caterini1,2, Laura Banks3,4, Greg D Wells1,5, Brian McCrindle4,6, and Mike Seed4,6

1Physiology and Experimental Medicine, Hospital for Sick Children, Toronto, ON, Canada, 2Department of Exercise Sciences, University of Toronto, Toronto, ON, Canada, 3Faculty of Kinesiology and Physical Education, University of Toronto, ON, Canada, 4Labatt Family Heart Centre, Hospital for Sick Children, Toronto, ON, Canada, 5Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON, Canada, 6Department of Pediatrics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada

This study provides a comparison of four commonly-used estimates of PWV to evaluate aortic stiffness, and compares these estimates of PWV with factors indicating cardiometabolic risk in obese youth. Hemodynamic parameters and phase-contrast CMR of the aortic arch at 3.0T were measured in 19 participants (12 obese, 7 normal-weight). Four methods of estimating PWV were used (cross-correlation, foot-to-foot, half-peak, area under the curve). There was an association between increasing measures of inflammation (C-reactive protein) and BMI, indicating that aortic PWV may be associated with changes in arterial stiffness in adolescents with subclinical biomarkers of cardiovascular disease. Careful consideration should be given to the method of PWV estimation due to measurement bias.

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