A pilot study of perfusion-related signal component in fMRI signal, demonstrates possibility of measuring blood transit time variation by tracking BOLD lag through the vascular structure. Effect of short breath-holding and mild hyperventilation on the time-shift analysis of whole-brain BOLD signals were tested. Temporal variation of the relative BOLD transit time up to ±15% on average were found to be negatively correlated with the global BOLD signal change, which is consistent with the Central Volume Principle under the condition of small CBV change. This relative BOLD transit time is likely to reflect the global CBF/CBV dynamics with high temporal resolution.
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