Abstract #2794

Precision and Reproducibility of Cardiac Phase Resolved Ventricular Volumetry using 4D MUSIC MRI in Congenital Heart Disease

Takegawa Yoshida^1,2, Kim-Lien Nguyen^1,3, Maxine Tang³, Fei Han^1,2, Peng Hu^1,2, and Paul Finn^1,2,3

¹Diagnostic Cardiovascular Imaging Laboratory, David Geffen School of Medicien at UCLA, Los Angeles, CA, United States, ²Department of Radiology, David Geffen School of Medicien at UCLA, Los Angeles, CA, United States, ³Department of Medicine, David Geffen School of Medicien at UCLA, Los Angeles, CA, United States

Precise and reproducible quantification of ventricular function and volume, particularly right ventricular volumetry, is important in congenital heart disease. Accurate quantification is highly dependent on accurate delineation of myocardial borders. Ferumoxytol-enhanced MUSIC provides multiphase, high resolution, dynamic 3D imaging of the whole heart. We evaluated the precision and reproducibility of ventricular function and volumetric measurements using a commercial 3D image design and modeling software whose segmentation algorithm takes into account partial volume effects (Mimics, Materialise). We demonstrate that quantification of ventricular function and volumetry for 4D MUSIC images using Mimics is reproducible with high intra-class correlation coefficient.

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