Abstract #2776

Molecular Magnetic Resonance Imaging of Vascular Myeloperoxidase Activity for the Identification of Unstable Atherosclerotic Plaque

Imran Rashid¹, David Cheng¹, Jihan Talib¹, Ghassan J Maghzal¹, Andre Bongers², Ren Minqin³, and Roland Stocker¹

¹Vascular Biology Division, Victor Chang Cardiac Research Institute, Sydney, NSW, Australia, ²Biological Resources Imaging Laboratory, University of New South Wales, Sydney, Australia, ³Department of Physics, Centre for Beam Applications, National University of SIngapore, Singapore, Singapore

Non-invasive imaging of unstable atherosclerotic plaques prone to rupture remains an unmet need in clinical cardiology. This is because current imaging modalities provide information on plaque burden, luminal stenosis and calcification, whereas they have limited ability to discern unstable from stable plaques. We used the tandem stenosis mouse model of unstable plaque in conjunction with MRI and a sensor (bis-5-hydroxytryptamide-DTPA-Gd) for the activity of the inflammatory enzyme myeloperoxidase. Our results reveal sustained and greater enhancement of unstable experimental plaque with the targeted sensor compared with its non-targeted analog (DTPA-Gd), and these results were confirmed by separate biochemical and histological analyses.

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