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Abstract #2730

Gender-based optimization of cardiac follow up in thalassemia major patients

Antonella Meloni1, Laura Pistoia2, Silvia Maffei1, Giuseppe Peritore3, Valentina Vinci4, Massimiliano Missere5, Vincenzo Positano2, Massimo Allò6, Antonella Massa7, and Alessia Pepe1

1Fondazione G. Monasterio CNR-Regione Toscana, Pisa, Italy, 2CMR Unit, Fondazione G. Monasterio CNR-Regione Toscana, Pisa, Italy, 3"ARNAS" Civico, Di Cristina Benfratelli, Palermo, Italy, 4Azienda Ospedaliera "Garibaldi" Presidio Ospedaliero Nesima, Catania, Italy, 5Fondazione di Ricerca e Cura "Giovanni Paolo II", Campobasso, Italy, 6Presidio Ospedaliero ASL 5, Crotone, Italy, 7Ospedale “Giovanni Paolo II”, Olbia, Italy

Females seem to tolerate iron toxicity better, possibly as an effect of reduced sensitivity to chronic oxidative stress. Based on our data about the significantly different risk in developing cardiac complications, in females older than 20 years the FU may be performed every 24 months, thus optimizing health care costs.

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Abstract