Abstract #2721

Towards High Success Rate in vivo Cardiac DTI on a Clinical 3T Scanner: Considerations on Heart Rate, Body-to-Mass Index, and Free Breathing

Christopher Nguyen¹, Sen Ma^1,2, Xiaoming Bi³, and Debiao Li^1,2

¹Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ²Bioengineering, University of California Los Angeles, Los Angeles, CA, United States, ³Siemens Healthcare, Los Angeles, CA, United States

Clinical translation of cardiac diffusion tensor MRI has been challenging because of the sensitivity to bulk motion and thus, low success rates of scans. Current techniques require either high gradient systems (>40 mT/m) or excess breath holding ( >10 breath holds / slice) to acquire motion free cardiac DT-MRI. We propose a cardiac DT-MRI technique optimized for clinical translation and aimed at achieving high success rates in subjects with high and variable heart rate and high bold-to-mass index under free breathing conditions. Results in subjects with high BMI and variable HR yielded success rates > 90%.

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