Targeted magnetic drug delivery could reduce toxicity of transarterial chemoembolization when used in combination with a magnetic filtration device, and accurate quantification is necessary. We utilized 89Zr-iron oxide nanoparticles (IONP) to evaluate quantitative susceptibility mapping (QSM), R2*, and 89Zr-PET uptake. Phantom evaluations demonstrated linear correlation between QSM, R2*, and 89Zr-PET/MR. Substantial increase in QSM and R2* was observed in a single hepatic lobe in a preliminary in vivo experiment after injection using MR only. These cross-validated techniques demonstrate a linear relationship between IONP concentration and QSM, R2*, and 89Zr-PET in vitro and show promise in assessing magnetic nanoparticle tracking.
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