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Abstract #2595

In Vivo 19F MRI for Non-invasively Investigating the Effects of Perfluorocarbon Nanoemulsion on High Intensity Focused Ultrasound Tumor Ablation

Soo Hyun Shin1, Eun-Joo Park2, Changki Min1, Sun Il Choi1, Soyeon Jeon1, Yun-Hee Kim1, and Daehong Kim1

1Molecular Imaging & Therapy Branch, National Cancer Center, Goyang, Korea, Republic of, 2Dept. of Radiology, Seoul National University Hospital, Seoul, Korea, Republic of

Perfluorocarbon nanoemulsion (PFCNE) is currently studied as a precursor of microbubbles to accompany high intensity focused ultrasound (HIFU) for tumor ablation. We propose 19F MRI as a valuable tool for non-invasively assessing the effects of PFCNE concentration on therapeutic efficiency of HIFU. 19F MRI was used to determine the amount of PFCNE accumulated in a tumor before HIFU treatment. Tumor ablation was monitored by intra-voxel incoherent motion (IVIM) mapping, which was compared with PFCNE quantification from 19F MRI for identifying the PFCNE concentration that gives optimal therapeutic efficiency.

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