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Abstract #2569

Assessment of brain volume and shape abnormalities in chemotherapy-treated breast cancer survivors using voxel-based morphometry and vertex-wise shape analysis

TzyShyuan Ng1, Vincent Chin-Hung Chen2,3, Dah-Cherng Yeh4, Ren-Horng Wang1, and Jun-Cheng Weng1,5

1Department of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung, Taiwan, 2School of Medicine, Chang Gung University, Taoyuan, Taiwan, 3Department of Psychiatry, Chang Gung Memorial Hospital, Chiayi, Taiwan, 4Breast Center, Taichung Tzu Chi Hospital, Taichung, Taiwan, 5Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung, Taiwan

Cancer-related trauma after chemotherapy has been widely reported by breast cancer. The previous study consistently showed lower gray and white matter volume and density in patients treated with chemotherapy. The aim of this study was to find out the early effect in both brain volume and shape in the chemotherapy-treated breast cancer patients compared to healthy controls using voxel-based morphometry (VBM) and vertex-wise shape analyses, respectively. Our results showed significant changes in the brain structural volume and shape, particularly in the putamen and hippocampus.

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Abstract