We investigate the potential of a technique to automatize quantification of neuronal damage from T1-weighted MR scans in multiple sclerosis patients. T1 hypointense component measures in the deep nuclei are derived from 40 MPRAGE scans (21 relapsing-remitting MS and 19 age-matched controls) through combined brain tissue classification and atlas-based segmentation algorithms. Our analysis shows that these automated measures are significantly lower in the thalamus and putamen of MS patients, which is in line with previously reported loss of structure in these regions.
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