Differentiation MS lesions from ischemic demyelinating lesions is important because of their totally different treatment strategies. Our results suggested that the increased susceptibility of demyelinating lesions, the presence of QSM-ring lesions and the central vein in the lesions helped to differentiate MS lesions from ischemic demyelinating lesions. Thus, QSM provided the underling iron-related pathogenesis of MS lesions, which enable to differentiate MS lesions from ischemic demyelinating lesions.
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