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Abstract #2523

First Application of 7T Structural, Vascular, and Diffusion Imaging to Trigeminal Neuralgia: Preliminary Results in Patients

Judy Alper1,2, Rafael O'Halloran3, Bradley Delman4, Raj Shrivastava5, and Priti Balchandani1

1Radiology, Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 2Biomedical Engineering, City University of New York, New York, NY, United States, 3Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 4Neuroradiology, Mount Sinai Medical Center, New York, NY, United States, 5Neurosurgery and Otolaryngology, Mount Sinai Medical Center, New York, NY

Trigeminal neuralgia (TN) is a debilitating condition characterized by severe facial pain. The pathophysiology of TN is not well understood and conventional clinical imaging often fails to identify the anatomical source of pain. In this study, we perform high-resolution 7T structural, vascular and diffusion-weighted MRI to visualize the trigeminal nerve region in three TN patients and three controls. We found that 7T-MRI provided improved visualization of nerve abnormalities compared to clinical scans. We also found greater nerve asymmetry in TN patients compared to controls. Multi-modal 7T-MRI could enhance our understanding of TN etiology and provide improved clinical outcomes for TN.

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Abstract