Abstract #2510

Reproducible fast T1 mapping of the human cervical spinal cord in vivo

Marco Battiston¹, Torben Schneider², Ferran Prados^1,3, Francesco Grussu¹, Marios C Yiannakas¹, Sebastien Ourselin³, Claudia A M Gandini Wheeler-Kingshott^1,4,5, and Rebecca S Samson¹

¹UCL Institute of Neurology, Queen Square MS Centre, UCL, London, United Kingdom, ²Philips Healthcare, Guilford, United Kingdom, ³Translational Imaging Group, Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, UCL, London, United Kingdom, ⁴Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy, ⁵Brain MRI 3T Mondino Research Center, C. Mondino National Neurological Institute, Pavia, Italy

The T₁ relaxation time is a fundamental quantitative Magnetic Resonance parameter widely used to characterize healthy and pathological tissue. However, quantitative T₁ mapping in the human spinal cord (SC) has been limited to date, mainly due to its small size and sensitivity to artefacts. Here we assess the reproducibility of a time efficient (<5min) SC protocol for Inversion Recovery T₁ mapping, which is considered the gold-standard method for T₁ estimation. Scan-rescan experiments were performed in a cohort of 4 healthy subjects. High reproducibility (whole cord intraclass correlation=0.94) of T₁ estimates was found, with whole cord intra-subject coefficient-of-variation<15% for all subjects.

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