Exercise is potentially therapeutic via vascular adaptations (angiogenesis, improved cerebral perfusion and metabolism) however the underlying dynamics are not fully understood. In Huntington´s disease (HD), where the therapeutic potential of exercise is being explored, cerebral vasculature alterations have been reported.
Here we used arterial spin labelling to examine the acute effect of aerobic exercise on the cerebrovasculature in HD patients. We show that genetic disease load is related to both baseline cerebral blood flow (CBF) and the exercise-induced change in CBF.
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