Iron levels in the basal ganglia in Huntington’s disease (HD) have been previously investigated at 3T with MRI using magnetic field correlation imaging, T2*, quantitative susceptibility mapping (QSM), as well as T2 relaxometry mostly at lower fields of 1.5T or less. We performed T2 mapping at 3T in a group of pre-HD (n=10) and HD patients (n=11) to investigate its association with Disease Burden Score and structural measures (caudate volume) of disease load. We found significant correlations between T2 and disease progression measures in nucleus accumbens, putamen and pallidum.
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