Abstract #2447

Modulation of the peri-infarct neurovascular function by Beta-Hydroxybutyrate

Paolo Bazzigaluppi¹, Evelyn Lake², Margaret Koletar³, Rafal Janik⁴, James Mester⁵, Conner Adams⁶, Peter Carlen⁷, and Bojana Stefanovic⁴

¹Medical biophysics, Sunnybrook Research institute, Toronto, ON, Canada, ²Yale University, CT, United States, ³Sunnybrook Research Institute, ⁴Sunnybrook Research Institute, ON, Canada, ⁵Sunnybrook Research Center, ON, Canada, ⁶ON, Canada, ⁷Krembil Research Intitute, Toronto, ON, Canada

In view of the failure of neurocentric treatments for ischemic stroke, this work examines a pleiotropic modulation of the neurogliovascular unit exerts beneficial effects in the treatment of brain stroke. Oxydative metabolism of glucose in the peri-ischemic tissue has potentially detrimental effects on tissue; in contrast, ketones’ metabolism - in light of the reduced amount of oxygen required - provides a safer alternative. We employed functional CASL, in situ electrophysiology, and biochemical analysis to show short-term benefits of early administration of β-Hydroxybutyrate to metabolically challenged brain tissue following focal ischemia.

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